Evaluation of serum irisin, retinol-binding protein-4 in human obesity
نویسندگان
چکیده
Retinol-binding protein 4(RBP4), and irisin originally described as an adipocyte-specific hormone, has been suggested to be important link between obesity, insulin resistance diabetes. To test the hypothesis that RBP4, concentrations will higher in obese subject than normal weight. A total of 176 individuals were evaluated, which divided into three groups according BMI. Group I (Normal Weight group n=75), II (Over group, n=50), III (Obese n=51). Serum RBP4and levels evaluated by enzyme-linked immunosorbent assay. The statistical analysis (students t-test) exhibited significant (P> 0.0001)elevation for RBP4 , Irisin, over weight compared with groups{(57.6 ± 16.0), (70.1 19.9)vs (41.8 13.3) µg/ml ; p< 0.001},{(168.19 11.71) (171.35 11.81) vs(146.19 9.13) ng/mL: 0.05},{(7.25 2.04), (9.02 4.75) vs (4.91±1.87) mU/mL; 0.001} respectively. Linear regression showed positive correlations serum and, Irisin.
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ژورنال
عنوان ژورنال: GSC biological and pharmaceutical sciences
سال: 2021
ISSN: ['2581-3250']
DOI: https://doi.org/10.30574/gscbps.2021.15.1.0100